KMID : 0606920090170030263
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Biomolecules & Therapeutics 2009 Volume.17 No. 3 p.263 ~ p.269
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Evaluation on Pharmacological Activities of 2,4-Dihydroxybenzaldehyde
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Jeong Hyeon-Joo
Lim Chang-Jin Song Yun-Seon Park Eun-Hee
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Abstract
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4-Hydroxybenzaldehyde, a phenolic compound found in a variety of natural sources, was previously shown to contain anti-inflammatory and related anti-angiogenic and anti-nociceptive activities. The present work was designed to assess some pharmacological activities of 2,4-dihydroxybenzaldehyde (DHD), an analogue of 4-hydroxybenzaldehyde. DHD exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis, and its IC50 value was 2.4 ?g/egg. DHD also contained in vivo anti- inflammatory activity using acetic acid-induced permeability and carrageenan-induced air pouch models in mice. In the air pouch model, DHD showed significant suppression in exudate volume, number of polymorphonuclear leukocytes and nitrite content. DHD showed an anti-nociceptive activity in the acetic acid-induced writhing test in mice. It also suppressed enhanced production of nitric oxide (NO) and elevated expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. It was able to slightly decrease the level of reactive oxygen species in the stimulated macrophages. DHD at the used concentrations couldn¡¯t modulate the viabilities of RAW264.7 cells. Taken together, like 4-hydroxybenzaldehyde, DHD contains anti-angiogenic, anti-inflammatory and anti-nociceptive activities.
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KEYWORD
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Anti-angiogenic, Anti-inflammatory, Anti-nociceptive, Cyclooxygenase-2, 2, 4-dihydroxybenzaldehyde, inducible nitric oxide synthase, Nitric oxide, RAW264.7, Reactive oxygen species
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